Материал: guidelines_atherosclerosis_2020

Литература

0F'HUPRWW 00 .UDPHU &0 7LDQ / &DUU - *XUDOQLN -0 3RORQVN\ 7 &DUUROO 7 .LEEH 0 &ULTXL 0+ )HUUXFFL / =KDR / +LSSH '6 :LONLQV - ;X ' /LDR < 0F&DUWK\ : <XDQ & 3ODTXH &RPSRVLWLRQ LQ WKH 3UR[LPDO 6XSHUILFLDO )HPRUDO $UWHU\ DQG 3HULSKHUDO $UWHU\ 'LVHDVH (YHQWV -$&& &DUGLRYDVFXODU ,PDJLQJ ă GRLMMFPJ

6LOOHVHQ + 6DUWRUL 6 6DQGKROW % %DEHU 8 0HKUDQ 5 )XVWHU 9 &DURWLG SODTXH WKLFNQHVV DQG FDURWLG SODTXH EXUGHQ SUHGLFW IXWXUH FDUGLRYDVFXODU HYHQWV LQ DV\PSWRPDWLF DGXOW $PHULFDQV (XURSHDQ +HDUW -RXUQDO &DUGLRYDVFXODU ,PDJLQJ ă GRL HKMFL MH[

3HUURQH )LODUGL 3 $FKHQEDFK 6 0RKOHQNDPS 6 5HLQHU = 6DPEXFHWL * 6FKXLMI -' 9DQ GHU :DOO ( .DXIPDQQ 3$

.QXXWL - 6FKURHGHU 6 =HOOZHJHU 0- &DUGLDF FRPSXWHG WRPRJUDSK\ DQG P\RFDUGLDO SHUIXVLRQ VFLQWLJUDSK\ IRU ULVN VWUDWLILFDWLRQ LQ DV\PSWRPDWLF LQGLYLGXDOV ZLWKRXW NQRZQ FDUGLRYDVFXODU GLVHDVH D SRVLWLRQ VWDWHPHQW RI WKH :RUNLQJ *URXS RQ 1XFOHDU &DUGLRORJ\ DQG &DUGLDF &7 RI WKH (XURSHDQ 6RFLHW\ RI &DUGLRORJ\ (XU +HDUW -ă GRL HXUKHDUWM HKT

'HQ 5XLMWHU +0 3HWHUV 6$( $QGHUVRQ 7- %ULWWRQ $5 'HNNHU -0 (LMNHPDQV 0- (QJVWU|P * (YDQV *: GH *UDDI - *UREEHH '( +HGEODG % +RIPDQ $ +ROHZLMQ 6 ,NHGD $ .DYRXVL 0 .LWDJDZD . .LWDPXUD $

.RIILMEHUJ + /RQQ (0 /RUHQ] 0: 0DWKLHVHQ (% 1LMSHOV * 2ND]DNL 6 2/HDU\ '+ 3RODN -) 3ULFH -) 5REHUWVRQ & 5HPEROG &0 5RVYDOO 0 5XQGHN 7 6DORQHQ -7 6LW]HU 0 6WHKRXZHU &' :LWWHPDQ -& 0RRQV .* %RWV 0/ &RPPRQ &DURWLG ,QWLPD 0HGLD 7KLFNQHVV 0HDVXUHPHQWV LQ &DUGLRYDVFXODU 5LVN 3UHGLFWLRQ -$0$ă GRL MDPD

6WHLQ -+ .RUFDU] &( +XUVW 57 /RQQ ( .HQGDOO &% 0RKOHU (5 1DMMDU 66 5HPEROG &0 3RVW :6 $PHULFDQ 6RFLHW\ RI (FKRFDUGLRJUDSK\ &DURWLG ,QWLPD 0HGLD 7KLFNQHVV 7DVN )RUFH 8VH RI &DURWLG 8OWUDVRXQG WR ,GHQWLI\ 6XEFOLQLFDO 9DVFXODU 'LVHDVH DQG (YDOXDWH &DUGLRYDVFXODU 'LVHDVH 5LVN $ &RQVHQVXV 6WDWHPHQW IURP WKH $PHULFDQ 6RFLHW\ RI (FKRFDUGLRJUDSK\ &DURWLG ,QWLPD 0HGLD 7KLFNQHVV 7DVN )RUFH (QGRUVHG E\ WKH 6RFLHW\ IRU 9DVFXODU 0HGLFLQH - $P 6RF (FKRFDUGLRJU ă GRL MHFKR

9ODFKRSRXORV & ;DSODQWHULV 3 $ER\DQV 9 %URGPDQQ 0 &íINRYá 5 &RVHQWLQR ) 'H &DUOR 0 *DOOLQR $ /DQGPHVVHU 8 /DXUHQW 6 /HNDNLV - 0LNKDLOLGLV '3 1DND .. 3URWRJHURX $' 5L]]RQL ' 6FhPLGW 7UXFNVäVV $ 9DQ %RUWHO / :HEHU 7 <DPDVKLQD $ =LPOLFhPDQ 5 %RXWRX\ULH 3 &RFNFURIW - 25RXUNH 0 3DUN -% 6FKLOODFL * 6LOOHVHQ + 7RZQVHQG 55 7KH UROH RI YDVFXODU ELRPDUNHUV IRU SULPDU\ DQG VHFRQGDU\ SUHYHQWLRQ $ SRVLWLRQ SDSHU IURP WKH (XURSHDQ 6RFLHW\ RI &DUGLRORJ\ :RUNLQJ *URXS RQ SHULSKHUDO FLUFXODWLRQ $WKHURVFOHURVLVă GRL MDWKHURVFOHURVLV

5RELQVRQ -* :LOOLDPV .- *LGGLQJ 6 %RUéQ - 7DEDV , )LVKHU ($ 3DFNDUG & 3HQFLQD 0 )D\DG =$ 0DQL 9 5\H .$ 1RUGHVWJDDUG %* 7yEMæUJ +DQVHQ $ 'RXJODV 36 1LFKROOV 6- 3DJLGLSDWL 1 6QLGHUPDQ $ (UDGLFDWLQJ WKH %XUGHQ RI $WKHURVFOHURWLF &DUGLRYDVFXODU 'LVHDVH E\ /RZHULQJ $SROLSRSURWHLQ % /LSRSURWHLQV (DUOLHU LQ /LIH - $P +HDUW $VVRF H GRL -$+$

.DPVWUXS 35 /LSRSURWHLQ D WKH FRPPRQ OLNHO\ FDXVDO \HW HOXVLYH ULVN IDFWRU IRU FDUGLRYDVFXODU GLVHDVH - /LSLG 5HV ă GRL MOUF

7VLPLNDV 6 )D]LR 6 )HUGLQDQG .& *LQVEHUJ +1 .RVFKLQVN\ 0/ 0DUFRYLQD 60 0RULDUW\ 30 5DGHU '- 5HPDOH\ $7 5H\HV 6RIIHU * 6DQWRV 5' 7KDQDVVRXOLV * :LW]WXP -/ 'DQWKL 6 2OLYH 0 /LX / 1+/%, :RUNLQJ *URXS 5HFRPPHQGDWLRQV WR 5HGXFH /LSRSURWHLQ D 0HGLDWHG 5LVN RI &DUGLRYDVFXODU 'LVHDVH DQG $RUWLF 6WHQRVLV - $P &ROO &DUGLRO ă GRL MMDFF

(FNHO 5+ -DNLFLF -0 $UG -' GH -HVXV -0 +RXVWRQ 0LOOHU 1 +XEEDUG 96 /HH ,0 /LFKWHQVWHLQ $+ /RULD &0 0LOOHQ %( 1RQDV &$ 6DFNV )0 6PLWK 6& -U 6YHWNH\ /3 :DGGHQ 7$ <DQRYVNL 6= .HQGDOO .$ 0RUJDQ /& 7ULVROLQL 0* 9HODVFR * :QHN - $QGHUVRQ -/ +DOSHULQ -/ $OEHUW 10 %R]NXUW % %ULQGLV 5* &XUWLV /+ 'H0HWV ' +RFKPDQ -6 .RYDFV 5- 2KPDQ (0 3UHVVOHU 6- 6HOONH ): 6KHQ :. 6PLWK 6& -U 7RPDVHOOL *)$+$ $&& *XLGHOLQH RQ /LIHVW\OH 0DQDJHPHQW WR 5HGXFH &DUGLRYDVFXODU 5LVN &LUFXODWLRQ VXSSO 6 6 GRL FLU G

GH /RUJHULO 0 6DOHQ 3 0DUWLQ - / 0RQMDXG , 'HOD\H - 0DPHOOH 1 0HGLWHUUDQHDQ 'LHW 7UDGLWLRQDO 5LVN )DFWRUV DQG WKH 5DWH RI &DUGLRYDVFXODU &RPSOLFDWLRQV $IWHU 0\RFDUGLDO ,QIDUFWLRQ &LUFXODWLRQ ă GRL FLU

(VWUXFK 5 5RV ( 6DODV 6DOYDGR - &RYDV 0, &RUHOOD ' $UyV ) *yPH] *UDFLD ( 5XL] *XWLpUUH] 9 )LRO 0 /DSHWUD - /DPXHOD 5DYHQWRV 50 6HUUD 0DMHP / 3LQWy ; %DVRUD - 0XxR] 0$ 6RUOt -9 0DUWtQH] -$ )LWy 0 *HD $ +HUQiQ 0$ 0DUWtQH] *RQ]áOH] 0$ 3ULPDU\ 3UHYHQWLRQ RI &DUGLRYDVFXODU 'LVHDVH ZLWK D 0HGLWHUUDQHDQ 'LHW 6XSSOHPHQWHG ZLWK ([WUD 9LUJLQ 2OLYH 2LO RU 1XWV 1 (QJO - 0HG H GRL 1(-0RD

0R]DIIDULDQ ' /HPDLWUH 51 .LQJ ,% 6RQJ ; +XDQJ + 6DFNV )0 5LPP (% :DQJ 0 6LVFRYLFN '6 3ODVPD 3KRVSKROLSLG /RQJ &KDLQ Ȧ )DWW\ $FLGV DQG 7RWDO DQG &DXVH 6SHFLILF 0RUWDOLW\ LQ 2OGHU $GXOWV $QQ ,QWHUQ 0HG ă GRL ă ă ă ă

/X = .RX : 'X % :X < =KDR 6 %UXVFR 2$ 0RUJDQ -0 &DSX]]L '0 &KLQHVH &RURQDU\ 6HFRQGDU\ 3UHYHQWLRQ 6WXG\ *URXS /L 6 (IIHFW RI ;XH]KLNDQJ DQ ([WUDFW )URP 5HG <HDVW &KLQHVH 5LFH RQ &RURQDU\ (YHQWV LQ D &KLQHVH 3RSXODWLRQ :LWK 3UHYLRXV 0\RFDUGLDO ,QIDUFWLRQ $P - &DUGLRO ă GRL M

DPMFDUG

33

¹1 2020

Литература

/L < -LDQJ / -LD = ;LQ : <DQJ 6 <DQJ 4 :DQJ / $ 0HWD $QDO\VLV RI 5HG <HDVW 5LFH $Q (IIHFWLYH DQG 5HODWLYHO\ 6DIH $OWHUQDWLYH $SSURDFK IRU '\VOLSLGHPLD 3/R6 2QH H GRL MRXUQDO SRQH

&KROHVWHURO 7UHDWPHQW 7ULDOLVWV¶ &77 &ROODERUDWLRQ %DLJHQW & %ODFNZHOO / (PEHUVRQ - +ROODQG /( 5HLWK & %KDOD 1 3HWR 5 %DUQHV (+ .HHFK $ 6LPHV - &ROOLQV 5 &KROHVWHURO 7UHDWPHQW 7ULDOLVWV &77 &ROODERUDWLRQ (IILFDF\ DQG VDIHW\ RI PRUH LQWHQVLYH ORZHULQJ RI /'/ FKROHVWHURO $ PHWD DQDO\VLV RI GDWD IURP SDUWLFLSDQWV LQ UDQGRPLVHG WULDOV /DQFHW ă

6HYHU 36 'DKO|I % 3RXOWHU 15 HW DO 3UHYHQWLRQ RI FRURQDU\ DQG VWURNH HYHQWV ZLWK DWRUYDVWDWLQ LQ K\SHUWHQVLYH SDWLHQWV ZKR KDYH DYHUDJH RU ORZHU WKDQ DYHUDJH FKROHVWHURO FRQFHQWUDWLRQV LQ WKH $QJOR 6FDQGLQDYLDQ &DUGLDF 2XWFRPHV 7ULDO²/LSLG /RZHULQJ $UP $6&27 //$ D PXOWLFHQWUH UDQGRPLVHG FRQWUROOHG WULDO /DQFHWă GRL V ă ă

&ROKRXQ +0 %HWWHULGJH '- 'XUULQJWRQ 31 :HGHO + %HHYHUV * &DXOILHOG 0 &ROOLQV 5 .MHOGVHQ 6(

.ULVWLQVVRQ $ 0F,QQHV *7 0HKOVHQ - 1LHPLQHQ 0 2%ULHQ ( 2VWHUJUHQ - $6&27 LQYHVWLJDWRUV 3ULPDU\ SUHYHQWLRQ RI FDUGLRYDVFXODU GLVHDVH ZLWK DWRUYDVWDWLQ LQ W\SH GLDEHWHV LQ WKH &ROODERUDWLYH $WRUYDVWDWLQ 'LDEHWHV 6WXG\ &$5'6 PXOWLFHQWUH UDQGRPLVHG SODFHER FRQWUROOHG WULDO /DQFHW ă GRLV ă ă

3HGHUVHQ 75 )DHUJHPDQ 2 .DVWHOHLQ -- 2OVVRQ $* 7LNNDQHQ 0- +ROPH , /DUVHQ 0/ %HQGLNVHQ )6 /LQGDKO & 6]DUHN 0 7VDL - ,QFUHPHQWDO 'HFUHDVH LQ (QG 3RLQWV 7KURXJK $JJUHVVLYH /LSLG /RZHULQJ ,'($/ 6WXG\ *URXS +LJK GRVH DWRUYDVWDWLQ YV XVXDO GRVH VLPYDVWDWLQ IRU VHFRQGDU\ SUHYHQWLRQ DIWHU P\RFDUGLDO LQIDUFWLRQ WKH ,'($/ VWXG\ D UDQGRPL]HG FRQWUROOHG WULDO -$0$ ă

%RHNKROGW 60 +RYLQJK *. 0RUD 6 $UVHQDXOW %- $PDUHQFR 3 3HGHUVHQ 75 /D5RVD -& :DWHUV '' 'H0LFFR '$ 6LPHV 5- .HHFK $& &ROTXKRXQ ' +LWPDQ *$ %HWWHULGJH '- &OHDUILHOG 0% 'RZQV -5 &ROKRXQ +0 *RWWR $0 -U 5LGNHU 30 *UXQG\ 60 .DVWHOHLQ -- 9HU\ ORZ OHYHOV RI DWKHURJHQLF OLSRSURWHLQV DQG WKH ULVN IRU FDUGLRYDVFXODU HYHQWV D PHWD DQDO\VLV RI VWDWLQ WULDOV - $P &ROO &DUGLRO ă

5LGNHU 30 'DQLHOVRQ ( )RQVHFD )$ *HQHVW - *RWWR $0 -U .DVWHOHLQ -- .RHQLJ : /LEE\ 3 /RUHQ]DWWL $- 0DF)DG\HQ -* 1RUGHVWJDDUG %* 6KHSKHUG - :LOOHUVRQ -7 *O\QQ 5- -83,7(5 6WXG\ *URXS 5RVXYDVWDWLQ WR SUHYHQW YDVFXODU HYHQWV LQ PHQ DQG ZRPHQ ZLWK HOHYDWHG & UHDFWLYH SURWHLQ 1 (QJO - 0HG ă

<XVXI 6 %RVFK - 'DJHQDLV * =KX - ;DYLHU ' /LX / 3DLV 3 /ySH] -DUDPLOOR 3 /HLWHU /$ 'DQV $ $YH]XP $ 3LHJDV /6 3DUNKRPHQNR $ .HOWDL . .HOWDL 0 6OLZD . 3HWHUV 5- +HOG & &KD]RYD , <XVRII . /HZLV %6 -DQVN\ 3 .KXQWL . 7RII :' 5HLG &0 9DULJRV - 6DQFKH] 9DOOHMR * 0F.HOYLH 5 3RJXH - -XQJ + *DR 3 'LD] 5 /RQQ ( +23( ,QYHVWLJDWRUV &KROHVWHURO /RZHULQJ LQ ,QWHUPHGLDWH 5LVN 3HUVRQV ZLWKRXW &DUGLRYDVFXODU 'LVHDVH 1 (QJO - 0HG ă GRL 1(-0RD

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ă GRL &,5&8/$7,21$+$

$PDUHQFR 3 %RJRXVVODYVN\ - &DOODKDQ $ *ROGVWHLQ /% +HQQHULFL 0 5XGROSK $( 6LOOHVHQ + 6LPXQRYLF / 6]DUHN 0 :HOFK .0 =LYLQ -$ 6WURNH 3UHYHQWLRQ E\ $JJUHVVLYH 5HGXFWLRQ LQ &KROHVWHURO /HYHOV 63$5&/ ,QYHVWLJDWRUV +LJK GRVH DWRUYDVWDWLQ DIWHU VWURNH RU WUDQVLHQW LVFKHPLF DWWDFN 1 (QJO - 0HGă GRL 1(-0RD

3DQGRU $ $UD 50 7XPXU , :LONLQVRQ $- 3DLVOH\ 6 'XHQDV $ 'XUULQJWRQ 31 &KLOFRWW - (]HWLPLEH PRQRWKHUDS\ IRU FKROHVWHURO ORZHULQJ LQ SHRSOH V\VWHPDWLF UHYLHZ DQG PHWD DQDO\VLV RI UDQGRPL]HG FRQWUROOHG WULDOV - ,QWHUQ 0HG 0D\ ă GRL M ă [

%DLJHQW & /DQGUD\ 0- 5HLWK & (PEHUVRQ - :KHHOHU '& 7RPVRQ & :DQQHU & .UDQH 9 &DVV $ &UDLJ - 1HDO % -LDQJ / +RRL /6 /HYLQ $ $JRGRD / *D]LDQR 0 .DVLVNH % :DONHU 5 0DVV\ =$ )HOGW 5DVPXVVHQ % .UDLULWWLFKDL 8 2SKDVFKDURHQVXN 9 )HOOVWUöP % +ROGDDV + 7HVDU 9 :LHFHN $ *UREEHH ' GH =HHXZ ' *UöQKDJHQ 5LVND & 'DVJXSWD 7 /HZLV ' +HUULQJWRQ : 0DIKDP 0 0DMRQL : :DOOHQGV]XV . *ULPP 5 3HGHUVHQ 7 7REHUW - $UPLWDJH - %D[WHU $ %UD\ & &KHQ < &KHQ = +LOO 0 .QRWW & 3DULVK 6 6LPSVRQ ' 6OHLJKW 3 <RXQJ $ &ROOLQV 5 6+$53 ,QYHVWLJDWRUV 7KH HIIHFWV RI ORZHULQJ /'/ FKROHVWHURO ZLWK VLPYDVWDWLQ SOXV H]HWLPLEH LQ SDWLHQWV ZLWK FKURQLF NLGQH\ GLVHDVH 6WXG\ RI +HDUW DQG 5HQDO 3URWHFWLRQ D UDQGRPLVHG SODFHER FRQWUROOHG WULDO /DQFHWă GRL 6 ă ă

$ELIDGHO 0 9DUUHW 0 5DEqV - 3 $OODUG ' 2XJXHUUDP . 'HYLOOHUV 0 &UXDXG & %HQMDQQHW 6 :LFNKDP / (UOLFK ' 'HUUé $ 9LOOéJHU / )DUQLHU 0 %HXFOHU , %UXFNHUW ( &KDPED] - &KDQX % /HFHUI -0 /XF * 0RXOLQ 3 :HLVVHQEDFK - 3UDW $ .UHPSI 0 -XQLHQ & 6HLGDK 1* %RLOHDX & 0XWDWLRQV LQ 3&6. FDXVH DXWRVRPDO GRPLQDQW K\SHUFKROHVWHUROHPLD 1DW *HQHW ă GRL QJ

1RUDWD *' 7LEROOD * &DWDSDQR $/ 7DUJHWLQJ 3&6. IRU +\SHUFKROHVWHUROHPLD $QQXDO 5HYLHZ RI 3KDUPDFRORJ\ DQG 7R[LFRORJ\ ă GRL DQQXUHY SKDUPWR[ ă

34

АТЕРОСКЛЕРОЗ И ДИСЛИПИДЕМИИ

Литература

&DQQRQ &3 %OD]LQJ 0$ *LXJOLDQR 53 0F&DJJ $ :KLWH -$ 7KHURX[ 3 'DULXV + /HZLV %6 2SKXLV 72 -XNHPD -: 'H )HUUDUL *0 5X]\OOR : 'H /XFFD 3 ,P . %RKXOD ($ 5HLVW & :LYLRWW 6' 7HUVKDNRYHF $0 0XVOLQHU 7$ %UDXQZDOG ( &DOLII 50 ,03529( ,7 ,QYHVWLJDWRUV (]HWLPLEH $GGHG WR 6WDWLQ 7KHUDS\ DIWHU $FXWH &RURQDU\ 6\QGURPHV 1 (QJO - 0HG ă GRL 1(-0RD

6DEDWLQH 06 *LXJOLDQR 53 .HHFK $& +RQDUSRXU 1 :LYLRWW 6' 0XUSK\ 6$ .XGHU -) :DQJ + /LX 7 :DVVHUPDQ 60 6HYHU 36 3HGHUVHQ 75 )285,(5 6WHHULQJ &RPPLWWHH DQG ,QYHVWLJDWRUV (YRORFXPDE DQG &OLQLFDO 2XWFRPHV LQ 3DWLHQWV ZLWK &DUGLRYDVFXODU 'LVHDVH 1 (QJO - 0HG ă GRL QHMPRD

*LXJOLDQR 53 3HGHUVHQ 75 3DUN - * 'H )HUUDUL *0 *DFLRQJ =$ &HVND 5 7RWK . *RXQL %HUWKROG , /RSH] 0LUDQGD - 6FKLHOH ) 0DFK ) 2WW %5 .DQHYVN\ ( 3LQHGD $/ 6RPDUDWQH 5 :DVVHUPDQ 60 .HHFK $& 6HYHU 36 6DEDWLQH 06 )285,(5 ,QYHVWLJDWRUV &OLQLFDO HIILFDF\ DQG VDIHW\ RI DFKLHYLQJ YHU\ ORZ /'/ FKROHVWHURO FRQFHQWUDWLRQV ZLWK WKH 3&6. LQKLELWRU HYRORFXPDE D SUHVSHFLILHG VHFRQGDU\ DQDO\VLV RI WKH )285,(5 WULDO /DQFHW ă GRL V ă ă

%RHNKROGW 60 +RYLQJK *. 0RUD 6 $UVHQDXOW %- $PDUHQFR 3 3HGHUVHQ 75 /D5RVD -& :DWHUV '' 'H0LFFR '$ 6LPHV 5- .HHFK $& &ROTXKRXQ ' +LWPDQ *$ %HWWHULGJH '- &OHDUILHOG 0% 'RZQV -5 &ROKRXQ +0 *RWWR $0 -U 5LGNHU 30 *UXQG\ 60 .DVWHOHLQ -- 9HU\ /RZ /HYHOV RI $WKHURJHQLF /LSRSURWHLQV DQG WKH 5LVN IRU &DUGLRYDVFXODU (YHQWV - $P &ROO &DUGLRO ă GRL MMDFF

6FKZDUW] ** 6WHJ 3* 6]DUHN 0 %KDWW '/ %LWWQHU 9$ 'LD] 5 (GHOEHUJ -0 *RRGPDQ 6* +DQRWLQ & +DUULQJWRQ 5$ -XNHPD -: /HFRUSV * 0DKDIIH\ .: 0RU\XVHI $ 3RUG\ 5 4XLQWHUR . 5RH 07 6DVLHOD :- 7DPE\ -) 7ULFRFL 3 :KLWH +' =HLKHU $0 2'<66(< 287&20(6 &RPPLWWHHV DQG ,QYHVWLJDWRUV $OLURFXPDE DQG &DUGLRYDVFXODU 2XWFRPHV DIWHU $FXWH &RURQDU\ 6\QGURPH 1 (QJO - 0HG ă GRL1(-0RD

&DVWHOOL :3 (SLGHPLRORJ\ RI WULJO\FHULGHV $ YLHZ IURP )UDPLQJKDP $P - &DUGLRO + + GRLă J

%DUWHU 3 *RWWR $0 /D5RVD -& 0DURQL - 6]DUHN 0 *UXQG\ 60 .DVWHOHLQ -- %LWWQHU 9 )UXFKDUW -& 7UHDWLQJ WR 1HZ 7DUJHWV ,QYHVWLJDWRUV +'/ &KROHVWHURO 9HU\ /RZ /HYHOV RI /'/ &KROHVWHURO DQG &DUGLRYDVFXODU (YHQWV 1 (QJO - 0HG ă GRL QHMPRD

&DUH\ 9- %LVKRS / /DUDQMR 1 +DUVKILHOG %- .ZLDW & 6DFNV )0 &RQWULEXWLRQ RI +LJK 3ODVPD 7ULJO\FHULGHV DQG /RZ +LJK 'HQVLW\ /LSRSURWHLQ &KROHVWHURO WR 5HVLGXDO 5LVN RI &RURQDU\ +HDUW 'LVHDVH $IWHU (VWDEOLVKPHQW RI /RZ 'HQVLW\ /LSRSURWHLQ &KROHVWHURO &RQWURO $P - &DUGLRO ă GRL M DPMFDUG

$JXLDU & $OHJULD ( %RQDGRQQD 5& &DWDSDQR $/ &RVHQWLQR ) (OLVDI 0 )DUQLHU 0 )HUULqUHV - )LODUGL 33 +DQFX 1 .D\LNFLRJOX 0 0HOOR ( 6LOYD $ 0LOODQ - 5HLQHUä 7RNJR]RJOX / 9DOHQVL 3 9LLJLPDD 0 9UDEOLN 0

=DPERQ $ =DPRUDQR -/ )HUUDUL 5 $ UHYLHZ RI WKH HYLGHQFH RQ UHGXFLQJ PDFURYDVFXODU ULVN LQ SDWLHQWV ZLWK DWKHURJHQLF G\VOLSLGDHPLD $ UHSRUW IURP DQ H[SHUW FRQVHQVXV PHHWLQJ RQ WKH UROH RI IHQRILEUDWHăVWDWLQ FRPELQDWLRQ WKHUDS\ $WKHURVFOHU 6XSSO ă GRL V ă ă

1DWLRQDO &KROHVWHURO (GXFDWLRQ 3URJUDP ([SHUW 3DQHO RQ 'HWHFWLRQ ( 7UHDWPHQW RI +LJK %ORRG &KROHVWHURO LQ $ 7KLUG 5HSRUW RI WKH 1DWLRQDO &KROHVWHURO (GXFDWLRQ 3URJUDP 1&(3 ([SHUW 3DQHO RQ 'HWHFWLRQ (YDOXDWLRQ DQG 7UHDWPHQW RI +LJK %ORRG &KROHVWHURO LQ $GXOWV $GXOW 7UHDWPHQW 3DQHO ,,, ILQDO UHSRUW &LUFXODWLRQă

+HJHOH 5$ *LQVEHUJ +1 &KDSPDQ 0- 1RUGHVWJDDUG %* .XLYHQKRYHQ -$ $YHUQD 0 %RUéQ - %UXFNHUW ( &DWDSDQR $/ 'HVFDPSV 26 +RYLQJK *. +XPSKULHV 6( .RYDQHQ 37 0DVDQD / 3DMXNDQWD 3 3DUKRIHU .* 5DDO )- 5D\ .. 6DQWRV 5' 6WDOHQKRHI $) 6WURHV ( 7DVNLQHQ 05 7\EMæUJ +DQVHQ $ :DWWV *) :LNOXQG 2 (XURSHDQ $WKHURVFOHURVLV 6RFLHW\ &RQVHQVXV 3DQHO 7KH SRO\JHQLF QDWXUH RI K\SHUWULJO\FHULGDHPLD LPSOLFDWLRQV IRU GHILQLWLRQ GLDJQRVLV DQG PDQDJHPHQW /DQFHW 'LDEHWHV (QGRFULQRO ă GRL 6 ăă

*KDQGHKDUL + .DPDO %DKO 6 :RQJ 1' 3UHYDOHQFH DQG H[WHQW RI G\VOLSLGHPLD DQG UHFRPPHQGHG OLSLG OHYHOV LQ 86 DGXOWV ZLWK DQG ZLWKRXW FDUGLRYDVFXODU FRPRUELGLWLHV 7KH 1DWLRQDO +HDOWK DQG 1XWULWLRQ ([DPLQDWLRQ 6XUYH\ă $P +HDUW - ă GRL MDKM

*LWW $. 'UH[HO + )HHO\ - )HUULqUHV - *RQ]DOH] -XDQDWH\ -5 7KRPVHQ .. /HLWHU /$ /XQGPDQ 3 GD 6LOYD 30 3HGHUVHQ 7 :RRG ' -üQJHU & 'HOOHD 36 6D]RQRY 9 &KD]HOOH ) .DVWHOHLQ -- '<6,6 ,QYHVWLJDWRUV 3HUVLVWHQW OLSLG DEQRUPDOLWLHV LQ VWDWLQ WUHDWHG SDWLHQWV DQG SUHGLFWRUV RI /'/ FKROHVWHURO JRDO DFKLHYHPHQW LQ FOLQLFDO SUDFWLFH LQ (XURSH DQG &DQDGD (XU - 3UHY &DUGLRO ă GRL

<XDQ * $O 6KDOL .= +HJHOH 5$ +\SHUWULJO\FHULGHPLD LWV HWLRORJ\ HIIHFWV DQG WUHDWPHQW &DQ 0HG $VVRF -ă GRL FPDM

5HDYHQ *0 &KHQ <' -HSSHVHQ - 0DKHX[ 3 .UDXVV 50 ,QVXOLQ UHVLVWDQFH DQG K\SHULQVXOLQHPLD LQ LQGLYLGXDOV ZLWK VPDOO GHQVH ORZ GHQVLW\ OLSRSURWHLQ SDUWLFOHV - &OLQ ,QYHVW ă GRL MFL

5LGNHU 30 5LIDL 1 &RRN 15 %UDGZLQ * %XULQJ -( 1RQă+'/ &KROHVWHURO $SROLSRSURWHLQV $ , DQG % 6WDQGDUG /LSLG 0HDVXUHV /LSLG 5DWLRV DQG &53 DV 5LVN )DFWRUV IRU &DUGLRYDVFXODU 'LVHDVH LQ :RPHQ -$0$

¹1 2020

Литература

(IIHFWV RI &RPELQDWLRQ /LSLG 7KHUDS\ LQ 7\SH 'LDEHWHV 0HOOLWXV 1 (QJO - 0HG ă GRL QHMPRD

%KDWW '/ 6WHJ 3* 0LOOHU 0 %ULQWRQ ($ -DFREVRQ 7$ .HWFKXP 6% 'R\OH 57 -U -XOLDQR 5$ -LDR / *UDQRZLW] & 7DUGLI -& %DOODQW\QH &0 5('8&( ,7 ,QYHVWLJDWRUV &DUGLRYDVFXODU 5LVN 5HGXFWLRQ ZLWK ,FRVDSHQW (WK\O IRU +\SHUWULJO\FHULGHPLD 1 (QJO - 0HG ă GRL QHMPRD

)UXFKDUW -& 'XULH] 3 0RGH RI DFWLRQ RI ILEUDWHV LQ WKH UHJXODWLRQ RI WULJO\FHULGH DQG +'/ FKROHVWHURO PHWDEROLVP 'UXJV RI 7RGD\ GRL GRW

.HDWLQJ *0 &URRP .) )HQRILEUDWH 'UXJV ă GRL ă ă

&KROHVWHURO 7UHDWPHQW 7ULDOLVWV¶ &77 &ROODERUDWLRQ %DLJHQW & %ODFNZHOO / (PEHUVRQ - +ROODQG /( 5HLWK & %KDOD 1 3HWR 5 %DUQHV (+ .HHFK $ 6LPHV - &ROOLQV 5 (IILFDF\ DQG VDIHW\ RI PRUH LQWHQVLYH ORZHULQJ RI /'/ FKROHVWHURO D PHWD DQDO\VLV RI GDWD IURP SDUWLFLSDQWV LQ UDQGRPLVHG WULDOV /DQFHWă GRL 6 ă ă

0DUN / 'DQL * )D]HNDV Ö 6]üOH 2 .RYDFV + .DWRQD $ (IIHFWV RI H]HWLPLEH RQ OLSLGV DQG OLSRSURWHLQV LQ SDWLHQWV ZLWK K\SHUFKROHVWHUROHPLD DQG GLIIHUHQW DSROLSRSURWHLQ ( JHQRW\SHV &XUU 0HG 5HV 2SLQă GRL [

.LP 1+ +DQ .+ &KRL - &KRL - /HH - .LP 6* 8VH RI IHQRILEUDWH RQ FDUGLRYDVFXODU RXWFRPHV LQ VWDWLQ XVHUV ZLWK PHWDEROLF V\QGURPH SURSHQVLW\ PDWFKHG FRKRUW VWXG\ %0- O GRL EPMO

(IIHFW RI IHQRILEUDWH RQ SURJUHVVLRQ RI FRURQDU\ DUWHU\ GLVHDVH LQ W\SH GLDEHWHV WKH 'LDEHWHV $WKHURVFOHURVLV ,QWHUYHQWLRQ 6WXG\ D UDQGRPLVHG VWXG\ /DQFHW ă GRL V ăă

%HVW - 6FRWW 5 7DVNLQHQ 05 )RUGHU 3 3LOODL $ 'DYLV 7 *ODV]LRX 3 'UXU\ 3 .HVlQLHPL <$ 6XOOLYDQ ' +XQW ' &ROPDQ 3 G(PGHQ 0 :KLWLQJ 0 (KQKROP & /DDNVR 0 ),(/' VWXG\ LQYHVWLJDWRUV (IIHFWV RI ORQJ WHUP IHQRILEUDWH WKHUDS\ RQ FDUGLRYDVFXODU HYHQWV LQ SHRSOH ZLWK W\SH GLDEHWHV PHOOLWXV WKH ),(/' VWXG\ UDQGRPLVHG FRQWUROOHG WULDO /DQFHW ă GRL V ă ă

.RYDFV &6 6HVKLDK 9 6ZDOORZ 5 -RQHV 5 5DWWXQGH + :RHUOH +- %URHGO 8& (03$ 5(* 3,2 WULDO LQYHVWLJDWRUV (PSDJOLIOR]LQ LPSURYHV JO\FDHPLF DQG ZHLJKW FRQWURO DV DGG RQ WKHUDS\ WR SLRJOLWD]RQH RU SLRJOLWD]RQH SOXV PHWIRUPLQ LQ SDWLHQWV ZLWK W\SH GLDEHWHV D ZHHN UDQGRPL]HG SODFHER FRQWUROOHG WULDO 'LDE 2EHV 0HWDE ă GRL GRP

=LQPDQ % :DQQHU & /DFKLQ -0 )LWFKHWW ' %OXKPNL ( +DQWHO 6 0DWWKHXV 0 'HYLQV 7 -RKDQVHQ 2( :RHUOH +- %URHGO 8& ,Q]XFFKL 6( (03$ 5(* 287&20( ,QYHVWLJDWRUV (PSDJOLIOR]LQ &DUGLRYDVFXODU 2XWFRPHV DQG 0RUWDOLW\ LQ 7\SH 'LDEHWHV 1 (QJO - 0HG ă GRL QHMPRD

0DUVR 63 'DQLHOV *+ %URZQ )UDQGVHQ . .ULVWHQVHQ 3 0DQQ -) 1DXFN 0$ 1LVVHQ 6( 3RFRFN 6 3RXOWHU 15 5DYQ /6 6WHLQEHUJ :0 6WRFNQHU 0 =LQPDQ % %HUJHQVWDO 50 %XVH -% /($'(5 6WHHULQJ &RPPLWWHH /($'(5 7ULDO ,QYHVWLJDWRUV /LUDJOXWLGH DQG &DUGLRYDVFXODU 2XWFRPHV LQ 7\SH 'LDEHWHV 1 (QJO - 0HGă GRL QHMPRD

0DUVR 63 %DLQ 6& &RQVROL $ (OLDVFKHZLW] )* -yGDU ( /HLWHU /$ /LQJYD\ , 5RVHQVWRFN - 6HXIHUW - :DUUHQ 0/ :RR 9 +DQVHQ 2 +ROVW $* 3HWWHUVVRQ - 9LOVE¡OO 7 6867$,1 ,QYHVWLJDWRUV 6HPDJOXWLGH DQG &DUGLRYDVFXODU 2XWFRPHV LQ 3DWLHQWV ZLWK 7\SH 'LDEHWHV 1 (QJO - 0HG ă GRL 1(-0RD

&RVHQWLQR ) *UDQW 3- $ER\DQV 9 %DLOH\ &- &HULHOOR $ 'HOJDGR 9 )HGHULFL 0 )LOLSSDWRV * *UREEHH '( +DQVHQ 7% +XLNXUL +9 -RKDQVVRQ , -üQL 3 /HWWLQR 0 0DU[ 1 0HOOELQ /* ÖVWJUHQ &- 5RFFD % 5RIIL 0 6DWWDU 1 6HIHURYLý 30 6RXVD 8YD 0 9DOHQVL 3 :KHHOHU '& (6& 6FLHQWLILF 'RFXPHQW *URXS (6& *XLGHOLQHV RQ GLDEHWHV SUH GLDEHWHV DQG FDUGLRYDVFXODU GLVHDVHV GHYHORSHG LQ FROODERUDWLRQ ZLWK WKH ($6' (XU +HDUW - GRL HXUKHDUWM HK]

(IIHFW RI LQWHQVLYH EORRG JOXFRVH FRQWURO ZLWK PHWIRUPLQ RQ FRPSOLFDWLRQV LQ RYHUZHLJKW SDWLHQWV ZLWK W\SH GLDEHWHV 8.3'6 /DQFHW ă GRL V ă ă

1RUGHVWJDDUG %* &KDSPDQ 0- +XPSKULHV 6( *LQVEHUJ +1 0DVDQD / 'HVFDPSV 26 :LNOXQG 2 +HJHOH 5$ 5DDO )- 'HIHVFKH -& :LHJPDQ $ 6DQWRV 5' :DWWV *) 3DUKRIHU .* +RYLQJK *. .RYDQHQ 37 %RLOHDX & $YHUQD 0 %RUéQ - %UXFNHUW ( &DWDSDQR $/ .XLYHQKRYHQ -$ 3DMXNDQWD 3 5D\ . 6WDOHQKRHI $) 6WURHV ( 7DVNLQHQ 05 7\EMæUJ +DQVHQ $ )DPLOLDO K\SHUFKROHVWHURODHPLD LV XQGHUGLDJQRVHG DQG XQGHUWUHDWHG LQ WKH JHQHUDO SRSXODWLRQ JXLGDQFH IRU FOLQLFLDQV WR SUHYHQW FRURQDU\ KHDUW GLVHDVH FRQVHQVXV VWDWHPHQW RI WKH (XURSHDQ $WKHURVFOHURVLV 6RFLHW\ (XU +HDUW - ă D GRL HXUKHDUWM HKW

5RVHQJUHQ $ %HWWHU WUHDWPHQW DQG LPSURYHG SURJQRVLV LQ HOGHUO\ SDWLHQWV ZLWK $0, EXW GR UHJLVWHUV WHOO WKH ZKROH WUXWK" (XU +HDUW - ă GRL HXUKHDUWM HKU

3URVSHFWLYH 6WXGLHV & /HZLQJWRQ 6 :KLWORFN * &ODUNH 5 6KHUOLNHU 3 (PEHUVRQ - +DOVH\ - 4L]LOEDVK 1 3HWR 5 &ROOLQV 5 %ORRG FKROHVWHURO DQG YDVFXODU PRUWDOLW\ E\ DJH VH[ DQG EORRG SUHVVXUH D PHWD DQDO\VLV RI LQGLYLGXDO GDWD IURP SURVSHFWLYH VWXGLHV ZLWK YDVFXODU GHDWKV /DQFHW ă GRL 6 ă ă

36

АТЕРОСКЛЕРОЗ И ДИСЛИПИДЕМИИ

Литература

6HFRQG -RLQW 7DVN )RUFH RI ( 3UHYHQWLRQ RI FRURQDU\ KHDUW GLVHDVH LQ FOLQLFDO SUDFWLFH 5HFRPPHQGDWLRQV RI WKH 6HFRQG -RLQW 7DVN )RUFH RI (XURSHDQ DQG RWKHU 6RFLHWLHV RQ &RURQDU\ 3UHYHQWLRQ (XU +HDUW -ă GRL HXKM

/OR\G -RQHV '0 /HLS (3 /DUVRQ 0* '$JRVWLQR 5% %HLVHU $ :LOVRQ 3: :ROI 3$ /HY\ ' 3UHGLFWLRQ RI /LIHWLPH 5LVN IRU &DUGLRYDVFXODU 'LVHDVH E\ 5LVN )DFWRU %XUGHQ DW <HDUV RI $JH &LUFXODWLRQă GRL FLUFXODWLRQDKD

%HUU\ -' '\HU $ &DL ; *DUVLGH '% 1LQJ + 7KRPDV $ *UHHQODQG 3 9DQ +RUQ / 7UDF\ 53 /OR\G -RQHV '0 /LIHWLPH 5LVNV RI &DUGLRYDVFXODU 'LVHDVH 1 (QJ - 0HG ă GRL QHMPRD

*LDQJ .: %MöUFN / 1RYDN 0 /DSSDV * :LOKHOPVHQ / 7RUéQ . 5RVHQJUHQ $ 6WURNH DQG FRURQDU\ KHDUW GLVHDVH SUHGLFWLYH SRZHU RI VWDQGDUG ULVN IDFWRUV LQWR ROG DJH²ORQJ WHUP FXPXODWLYH ULVN VWXG\ DPRQJ PHQ LQ *RWKHQEXUJ 6ZHGHQ (XU +HDUW - ă GRL HXUKHDUWM HKV

:LOKHOPVHQ / 6YlUGVXGG . (ULNVVRQ + 5RVHQJUHQ $ +DQVVRQ 32 :HOLQ & 2GéQ $ :HOLQ / )DFWRUV DVVRFLDWHG ZLWK UHDFKLQJ \HDUV RI DJH D VWXG\ RI PHQ ERUQ LQ LQ *RWKHQEXUJ 6ZHGHQ - ,QWHUQ 0HGă GRL M ă [

5HLQHUä 3ULPDU\ 3UHYHQWLRQ RI &DUGLRYDVFXODU 'LVHDVH ZLWK 6WDWLQV LQ WKH (OGHUO\ &XUU $WKHURVFOHU 5HSGRL V ă ă ă

6DYDUHVH * *RWWR $0 3DROLOOR 6 '$PRUH & /RVFR 7 0XVHOOD ) 6FDOD 2 0DUFLDQR & 5XJJLHUR ' 0DUVLFR ) 'H /XFD * 7ULPDUFR % 3HUURQH )LODUGL 3 %HQHILWV RI 6WDWLQV LQ (OGHUO\ 6XEMHFWV :LWKRXW (VWDEOLVKHG &DUGLRYDVFXODU 'LVHDVH - $P &ROO &DUGLRO ă GRL MMDFF

6KHSKHUG - %ODXZ *- 0XUSK\ 0% %ROOHQ (/ %XFNOH\ %0 &REEH 60 )RUG , *DZ $ +\ODQG 0 -XNHPD -:

.DPSHU $0 0DFIDUODQH 3: 0HLQGHUV $( 1RUULH - 3DFNDUG &- 3HUU\ ,- 6WRWW '- 6ZHHQH\ %- 7ZRPH\ & :HVWHQGRUS 5* 35263(5 VWXG\ JURXS 3UDYDVWDWLQ LQ HOGHUO\ LQGLYLGXDOV DW ULVN RI YDVFXODU GLVHDVH 35263(5 D UDQGRPLVHG FRQWUROOHG WULDO /DQFHW ă GRL V ă[

'HHGZDQLD 3 6WRQH 3+ %DLUH\ 0HU] &1 &RVLQ $JXLODU - .R\ODQ 1 /XR ' 2X\DQJ 3 3LRWURZLF] 5 6FKHQFN *XVWDIVVRQ . 6HOOLHU 3 6WHLQ -+ 7KRPSVRQ 3/ 7]LYRQL ' (IIHFWV RI ,QWHQVLYH 9HUVXV 0RGHUDWH /LSLG /RZHULQJ 7KHUDS\ RQ 0\RFDUGLDO ,VFKHPLD LQ 2OGHU 3DWLHQWV :LWK &RURQDU\ +HDUW 'LVHDVH &LUFXODWLRQă GRL FLUFXODWLRQDKD

0LHWWLQHQ 7$ 3\RUDOD . 2OVVRQ $* 0XVOLQHU 7$ &RRN 7- )DHUJHPDQ 2 %HUJ . 3HGHUVHQ 7 .MHNVKXV - &KROHVWHURO /RZHULQJ 7KHUDS\ LQ :RPHQ DQG (OGHUO\ 3DWLHQWV :LWK 0\RFDUGLDO ,QIDUFWLRQ RU $QJLQD 3HFWRULV &LUFXODWLRQ ă GRL FLU

+HDUW 3URWHFWLRQ 6WXG\ &ROODERUDWLYH *URXS 05& %+) +HDUW 3URWHFWLRQ 6WXG\ RI FKROHVWHURO ORZHULQJ ZLWK VLPYDVWDWLQ LQ KLJK ULVN LQGLYLGXDOV D UDQGRPLVHG SODFHERFRQWUROOHG WULDO /DQFHW ă GRL V ă ă

%DLJHQW & /DQGUD\ 0- 5HLWK & (PEHUVRQ - :KHHOHU '& 7RPVRQ & :DQQHU & .UDQH 9 &DVV $ &UDLJ - 1HDO % -LDQJ / +RRL /6 /HYLQ $ $JRGRD / *D]LDQR 0 .DVLVNH % :DONHU 5 0DVV\ =$ )HOGW 5DVPXVVHQ %

.UDLULWWLFKDL 8 2SKDVFKDURHQVXN 9 )HOOVWUöP % +ROGDDV + 7HVDU 9 :LHFHN $ *UREEHH ' GH =HHXZ ' *UöQKDJHQ 5LVND & 'DVJXSWD 7 /HZLV ' +HUULQJWRQ : 0DIKDP 0 0DMRQL : :DOOHQGV]XV . *ULPP 5 3HGHUVHQ 7 7REHUW - $UPLWDJH - %D[WHU $ %UD\ & &KHQ < &KHQ = +LOO 0 .QRWW & 3DULVK 6 6LPSVRQ ' 6OHLJKW 3 <RXQJ $ &ROOLQV 5 6+$53 ,QYHVWLJDWRUV 7KH HIIHFWV RI ORZHULQJ /'/ FKROHVWHURO ZLWK VLPYDVWDWLQ SOXV H]HWLPLEH LQ SDWLHQWV ZLWK FKURQLF NLGQH\ GLVHDVH 6WXG\ RI +HDUW DQG 5HQDO 3URWHFWLRQ D UDQGRPLVHG SODFHER FRQWUROOHG WULDO /DQFHW ă GRL 6 ă ă

7RQHOOL 0 :DQQHU & /LSLG 0DQDJHPHQW LQ &KURQLF .LGQH\ 'LVHDVH 6\QRSVLV RI WKH .LGQH\ 'LVHDVH ,PSURYLQJ *OREDO 2XWFRPHV &OLQLFDO 3UDFWLFH *XLGHOLQH $QQ ,QWHUQ 0HG ă GRLP ă

1DFL + %UXJWV - $GHV 7 &RPSDUDWLYH 7ROHUDELOLW\ DQG +DUPV RI ,QGLYLGXDO 6WDWLQV &LUF &DUGLRYDVF 4XDO 2XWFRPHV ă GRL FLUFRXWFRPHV

%UXFNHUW ( +D\HP * 'HMDJHU 6 <DX & %éJDXG % 0LOG WR 0RGHUDWH 0XVFXODU 6\PSWRPV ZLWK +LJK 'RVDJH 6WDWLQ 7KHUDS\ LQ +\SHUOLSLGHPLF 3DWLHQWV ²7KH 35,02 6WXG\ &DUGLRYDVF 'UXJV 7KHU ă GRL V ă ă ]

'DYLGVRQ 0+ &ODUN -$ *ODVV /0 .DQXPDOOD $ 6WDWLQ 6DIHW\ $Q $SSUDLVDO IURP WKH $GYHUVH (YHQW 5HSRUWLQJ 6\VWHP $P - &DUGLRO 6 6 GRL MDPMFDUG

0DUFXP =$ 9DQGH *ULHQG -3 /LQQHEXU 6$ )'$ GUXJ VDIHW\ FRPPXQLFDWLRQV D QDUUDWLYH UHYLHZ DQG FOLQLFDO FRQVLGHUDWLRQV IRU ROGHU DGXOWV $P - *HULDWU 3KDUPDFRWKHU ă GRL M DPMRSKDUP

&KDODVDQL 1 $OMDGKH\ + .HVWHUVRQ - 0XUUD\ 0' +DOO 6' 3DWLHQWV ZLWK HOHYDWHG OLYHU HQ]\PHV DUH QRW DW KLJKHU ULVN IRU VWDWLQ KHSDWRWR[LFLW\ *DVWURHQWHURORJ\ ă GRL M JDVWUR

37

¹1 2020