Материал: Донсков С.И., Мороков В.А. Группы крови человека. Руководство по иммуносерологии

Возможна ситуация, когда у человека с эритроцитами I + и наличием доброкачественных аутоанти-I-антител в сыворотке может наблюдаться серологическая картина, создающая видимость фенотипа «взрослый i». Если в сыворотке пациента есть неполные формы анти-I-антител, то его эритроциты могут быть блокированы ими и выглядеть как I-отрицательные. Если предполагается такая ситуация, эритроциты больного должны быть заготовлены и сохраняться до исследования при 37  оС, после чего их следует трехкратно отмыть физиологическим раствором, нагретым до 37–40  оС. После этого они могут быть исследованы в реакции с анти-I-антителами. Цель указанного методического приема заключается в том, чтобы предотвратить фиксацию сывороточных неполных анти-I-антител на эритроцитах и блокаду участков I-антигена.

Кроме случаев болезни холодовых агглютининов, некоторых вторичных холодовых гемолитических анемий, обусловленных аутоантителами, и других эпизодов гемолиза, антитела анти-I и анти-i не могут считаться причиной деструкции эритроцитов в организме. Даже у пациентов, подвергшихся гипотермии при хирургических процедурах, доказательств вызванной антителами анти-I или анти-i деструкции эритроцитов не получено».

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