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Significance of Helicobacter pylori and antihelicobacter therapy in the clinical course of gastroesophageal reflux disease
Karimov M.M., Akhmatkhodjaev A.A. The Republican Specialised Scientifcally-Practical Centre of Therapy and Medical Rehabilitation. Tashkent, Uzbekistan
Key words: gastroesophageal reflux disease, course, pH-metry, Helicobacter pylori, antihelicobater therapy.
40 patients with gastroesophageal reflux disease with concomitant Helicobacter pylori-associated disease of stomach as chronic gastritis type B and duodenal ulcer were examined. It is shown that presence of infection does not affect on intraesophogeal level of pH parameters. Use of triple therapy, including proton pump inhibitors (PPI), amoxicillin and metronidazol during 7 days positive infuence on esophageal pH as a using PPI only in patients with gastroesophageal reflux disease without infection. Using amoxicillin, claritromicin and PPI during 12 days facilitate of subcompensated disturbance of antacid dysfunction of stomach and increase content of bile gastric juice. The results of treatment of gastroesophageal reflux disease in this group of patients were worse than as compared to the levels in patients had been treated with antihelicobacter therapy during 7 days.